Efficacy of metoprolol combined with torasemide in elderly patients with degenerative valvular heart disease and heart failure and its influence on NT-proBNP levels

Objective: To investigate the efficacy of metoprolol combined with torasemide in elderly patients degenerative valvular heart disease (DVHD) and failure its influence on N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations.
 Methods: The records 129 DVHD ≥60 years old diagnosed treated our hospital from January 2020 to February 2022 were retrospectively selected. According treatment records, 62 received (Control-group), 67 (Observation-group). changes cardiac function, NT-proBNP inflammatory factor concentrations clinical analyzed compared between two groups before after treatment.
 Results: After treatment, left ventricular ejection fraction (LVEF), end-diastolic diameter (LVEDD) mitral ratio peak early late diastolic filling velocity (E/A) lower, a greater decrease Observation-group Control-group (P<0.05). interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) lower both groups, total was significantly higher than There no significant difference incidence adverse drug reactions (P>0.05).
 Conclusion: Metoprolol has therapeutic effect failure. This combination improved reduced good safety.
 doi: https://doi.org/10.12669/pjms.39.4.7465
 How cite this: Ren K, Feng J, Yang X, B, Guo Y. Efficacy levels. Pak J Med Sci. 2023;39(4):945-949. is an Open Access article distributed under terms Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.